Publications

“We demonstrate that I3C can modulate the gut microbiome during colitis in such a way that it prevents the overgrowth of potential pathogenic bacteria while selectively allowing antiinflammatory butyrate production, thereby inducing an antiinflammatory state.”

– JCI Insight. 2020 Jan 16;5(1):e127551. doi: 10.1172/jci.insight.127551.


“These data suggest that alterations in the gut microbiome lead to an anti-inflammatory T cell response, leading to attenuation of inflammation-driven CRC.”

– J Clin Med. 2020 Jun 9;9(6):1796. doi: 10.3390/jcm9061796.


“These studies reveal that PTSD patients could be susceptible to inflammation by epigenetic dysregulation of TP53, which alters the miRNA profile to favor a proinflammatory Th17 phenotype.”

– Front Immunol. 2022 Jan 4;12:815840. doi: 10.3389/fimmu.2021.815840.

  • Publications List

    Mitchell C, Staley S, Williams MC, Bogdon R, Roark K, Hailey M, Miranda K, Becker W, Dopkins N, Pena MM, Hogan KM, Baird M, Wilson K, Nagarkatti P, Nagarkatti M, Busbee PB. Regulation of Bacteroides acidifaciens by the aryl hydrocarbon receptor in IL-22-producing immune cells has sex-dependent consequential impact on colitis. Front Immunol , 19 August 2024. 15 - 2024. doi: 10.3389/fimmu.2024.1444045

    Saxena A, Mitchell , Bogdon R, Roark K, Wilson K, Stale S, Hailey M, Williams MC, Rutkovsky A, Nagarkatti P, Nagarkatti M, Busbee PB. Aryl hydrocarbon receptor regulats Muc2 productin indepenpently o IL-22 during colitis. IJMS. 2024 Feb 18; 25(4), 2404. doi: 10.3390/ijms25042404

    Miranda K, Becker W, Busbee PB, Dopkins N, Abdulla OA, Zhong Y, Zhang J, Nagarkatti M, Nagarkatti PS. CB1 deletion in immune cells causes exacerbation while deletion in non-immune cells attenuates obesity. iScience. 2022 Aug 24;25(9):104994. doi: 10.1016/j.isci.2022.104994.

    Busbee PB, Bam M, Yang X, Abdulla OA, Zhou J, Ginsberg JPJ, Aiello AE, Uddin M, Nagarkatti M, Nagarkatti PS. Dysregulated TP53 Among PTSD Patients Leads to Downregulation of miRNA let-7a and Promotes an Inflammatory Th17 Phenotype. Front Immunol. 2022 Jan 4;12:815840. doi: 10.3389/fimmu.2021.815840.

    Sultan M, Wilson K, Abdulla OA, Busbee PB, Hall A, Carter T, Singh N, Chatterjee S, Nagarkatti P, Nagarkatti M. Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome through Modulation of Microbiome in the Gut-Lung Axis. Cells. 2021 Nov 25;10(12):3305. doi: 10.3390/cells10123305.

    Abdulla OA, Neamah W, Sultan M, Alghetaa HK, Singh N, Busbee PB, Nagarkatti M, Nagarkatti P. The Ability of AhR Ligands to Attenuate Delayed Type Hypersensitivity Reaction Is Associated With Alterations in the Gut Microbiota. Front Immunol. 2021 Jun 29;12:684727. doi: 10.3389/fimmu.2021.684727.

    Neamah WH, Busbee PB, Alghetaa H, Abdulla OA, Nagarkatti M, Nagarkatti P. AhR Activation Leads to Alterations in the Gut Microbiome with Consequent Effect on Induction of Myeloid Derived Suppressor Cells in a CXCR2-Dependent Manner. Int J Mol Sci. 2020 Dec 17;21(24):9613. doi: 10.3390/ijms21249613.

    Becker W, Alrafas HR, Busbee PB, Walla MD, Wilson K, Miranda K, Cai G, Putluri V, Putluri N, Nagarkatti M, Nagarkatti PS. Cannabinoid Receptor Activation on Haematopoietic Cells and Enterocytes Protects against Colitis. J Crohns Colitis. 2021 Jun 22;15(6):1032-1048. doi: 10.1093/ecco-jcc/jjaa253.

    Bam M, Yang X, Busbee PB, Aiello AE, Uddin M, Ginsberg JP, Galea S, Nagarkatti PS, Nagarkatti M. Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype. Mol Med. 2020 Nov 14;26(1):110. doi: 10.1186/s10020-020-00238-3.

    Alrafas HR, Busbee PB, Chitrala KN, Nagarkatti M, Nagarkatti P. Alterations in the Gut Microbiome and Suppression of Histone Deacetylases by Resveratrol Are Associated with Attenuation of Colonic Inflammation and Protection Against Colorectal Cancer. J Clin Med. 2020 Jun 9;9(6):1796. doi: 10.3390/jcm9061796.

    Busbee PB, Menzel L, Alrafas HR, Dopkins N, Becker W, Miranda K, Tang C, Chatterjee S, Singh U, Nagarkatti M, Nagarkatti PS. Indole-3-carbinol prevents colitis and associated microbial dysbiosis in an IL-22-dependent manner. JCI Insight. 2020 Jan 16;5(1):e127551. doi: 10.1172/jci.insight.127551.

    Alrafas HR, Busbee PB, Nagarkatti M, Nagarkatti PS. Resveratrol Downregulates miR-31 to Promote T Regulatory Cells during Prevention of TNBS-Induced Colitis. Mol Nutr Food Res. 2020 Jan;64(1):e1900633. doi: 10.1002/mnfr.201900633.

    Al-Ghezi ZZ, Singh N, Mehrpouya-Bahrami P, Busbee PB, Nagarkatti M, Nagarkatti PS. AhR Activation by TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) Attenuates Pertussis Toxin-Induced Inflammatory Responses by Differential Regulation of Tregs and Th17 Cells Through Specific Targeting by microRNA. Front Microbiol. 2019 Oct 18;10:2349. doi: 10.3389/fmicb.2019.02349. eCollection 2019.

    Neamah WH, Singh NP, Alghetaa H, Abdulla OA, Chatterjee S, Busbee PB, Nagarkatti M, Nagarkatti P. AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes. J Immunol. 2019 Oct 1;203(7):1830-1844. doi: 10.4049/jimmunol.1900291.

    Al-Ghezi ZZ, Busbee PB, Alghetaa H, Nagarkatti PS, Nagarkatti M. Combination of cannabinoids, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), mitigates experimental autoimmune encephalomyelitis (EAE) by altering the gut microbiome. Brain Behav Immun. 2019 Nov;82:25-35. doi: 10.1016/j.bbi.2019.07.028.

    Sarkar S, Kimono D, Albadrani M, Seth RK, Busbee P, Alghetaa H, Porter DE, Scott GI, Brooks B, Nagarkatti M, Nagarkatti P, Chatterjee S. Environmental microcystin targets the microbiome and increases the risk of intestinal inflammatory pathology via NOX2 in underlying murine model of Nonalcoholic Fatty Liver Disease. Sci Rep. 2019 Jun 19;9(1):8742. doi: 10.1038/s41598-019-45009-1.

    Chitrala KN, Yang X, Busbee B, Singh NP, Bonati L, Xing Y, Nagarkatti P, Nagarkatti M. Computational prediction and in vitro validation of VEGFR1 as a novel protein target for 2,3,7,8-tetrachlorodibenzo-p-dioxin. Sci Rep. 2019 May 2;9(1):6810. doi: 10.1038/s41598-019-43232-4.

    Alrafas HR, Busbee PB, Nagarkatti M, Nagarkatti PS. Resveratrol modulates the gut microbiota to prevent murine colitis development through induction of Tregs and suppression of Th17 cells. J Leukoc Biol. 2019 Aug;106(2):467-480. doi: 10.1002/JLB.3A1218-476RR.

    Alghetaa H, Mohammed A, Sultan M, Busbee P, Murphy A, Chatterjee S, Nagarkatti M, Nagarkatti P. Resveratrol protects mice against SEB-induced acute lung injury and mortality by miR-193a modulation that targets TGF-β signalling. J Cell Mol Med. 2018 May;22(5):2644-2655. doi: 10.1111/jcmm.13542.

    Chitrala KN, Guan H, Singh NP, Busbee B, Gandy A, Mehrpouya-Bahrami P, Ganewatta MS, Tang C, Chatterjee S, Nagarkatti P, Nagarkatti M. CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice. Eur J Immunol. 2017 Jul;47(7):1188-1199. doi: 10.1002/eji.201646792.

    Busbee PB, Nagarkatti M, Nagarkatti PS. Natural indoles, indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), attenuate staphylococcal enterotoxin B-mediated liver injury by downregulating miR-31 expression and promoting caspase-2-mediated apoptosis. PLoS One. 2015 Feb 23;10(2):e0118506. doi: 10.1371/journal.pone.0118506.

    Busbee PB, Nagarkatti M, Nagarkatti PS. Natural indoles, indole-3-carbinol and 3,3'-diindolymethane, inhibit T cell activation by staphylococcal enterotoxin B through epigenetic regulation involving HDAC expression. Toxicol Appl Pharmacol. 2014 Jan 1;274(1):7-16. doi: 10.1016/j.taap.2013.10.022.

    Singh UP, Singh NP, Guan H, Busbee B, Price RL, Taub DD, Mishra MK, Fayad R, Nagarkatti M, Nagarkatti PS. The emerging role of leptin antagonist as potential therapeutic option for inflammatory bowel disease. Int Rev Immunol. 2014 Jan;33(1):23-33. doi: 10.3109/08830185.2013.809071.

    Busbee PB, Rouse M, Nagarkatti M, Nagarkatti PS. Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders. Nutr Rev. 2013 Jun;71(6):353-69. doi: 10.1111/nure.12024.

    Singh UP, Singh NP, Guan H, Busbee B, Price RL, Taub DD, Mishra MK, Fayad R, Nagarkatti M, Nagarkatti PS. Leptin antagonist ameliorates chronic colitis in IL-10⁻/⁻ mice. Immunobiology. 2013 Dec;218(12):1439-51. doi: 10.1016/j.imbio.2013.04.020.

    Singh UP, Singh NP, Busbee B, Guan H, Singh B, Price RL, Taub DD, Mishra MK, Nagarkatti M, Nagarkatti PS. Int Rev Immunol. 2012 Feb;31(1):66-84. doi: 10.3109/08830185.2011.642909.